Help shape the future of treatment for Postpartum Depression.

CVS Life Sciences Solutions complies with Federal civil rights laws and does not discriminate on the basis of race, color, national origin, age, disability, or sex. CVS Life Sciences Solutions does not exclude people or treat them less favorably because of race, color, national origin, age, disability, or sex. CVS Life Sciences Solutions also provides people with disabilities with reasonable modifications and free appropriate auxiliary aids and services to communication with study team staff.

If you have any additional questions or concerns around this policy, you can contact the study team at eConsentsupport@CVSHealth.com or call 855-238-1769.

You can file a grievance with the CVS Civil Rights Coordinator via mail, fax, or email.

CVS Civil Rights Coordinator
Attn: 1557 Coordinator
CVS Pharmacy, Inc.
1 CVS Drive, MC 2232,
Woonsocket, RI 02895
Fax: 1-401-652-9935
Email: Coordinator1557@CVSHealth.com

If you have questions about your ZURZUVAE (zuranolone) prescription, please contact the CVS Health® Specialty Pharmacy at 1-866-933-4779.

The resources below may be helpful but please remember the information provided here is not intended to replace the advice of your clinician, primary care provider and/or your health care team, as they are the best source of information for any medical or health care needs.

National Maternal Mental Health Hotline
A free, confidential hotline providing support before, during, and after pregnancy by calling 1-833-1852-6262 (1-833-TLC-MAMA). Available 24/7 in English and Spanish. You can also visit mmhla.org to learn more.

Postpartum Support International (PSI)
The PSI mission is to promote awareness, prevention, and treatment of mental health issues related to childbearing. You can contact the PSI Helpline by calling 1-800-944-4773 and pressing #1 for Spanish or #2 for English. You can also text 'Help' to 800-944-4773 for English or to 971-203-7773 for Spanish. Resources, information, and other support is available by visiting postpartum.net.

March of Dimes
An organization supporting moms and babies with research, education, advocacy, and programs to be healthy and strong. You can also visit marchofdimes.org to learn more.

Shades of Blue Project
An organization dedicated to helping women of color before, during, and after childbirth with community resources, mental health advocacy, treatment, and support. To learn more visit shadesofblueproject.org.

The groups and associations listed above are not all of the organizations that support adults living with postpartum depression (PPD). This list of organizations is provided for your information only and is not an endorsement, referral, or recommendation from CVS Life Sciences Solutions or Biogen Inc.

People in crisis should call their local emergency number or the confidential National Suicide & Crisis Lifeline 24/7 at 988.

Call your doctor or healthcare provider for medical advice about side effects. To report suspected adverse reactions or side effects, you can contact Biogen at 1-844-987-9882 or the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

This research study is an observational, non-interventional study that helps to answer important questions about medications or treatments. An observational, non-interventional study is a study where researchers observe participants without intervening or making changes to your treatment plan and does not involve your clinician. This study is helping to answer questions such as how effective a treatment or a medication works for a certain condition.

For this specific study, researchers are collecting information on how well ZURZUVAE (zuranolone) works in reducing depressive symptoms for PPD through participant-reported surveys.

CVS Life Sciences Solutions is one of many businesses owned and operated by CVS Health®. You may have visited or provided your contact information to one of our CVS Minute Clinic® and/or Pharmacies, for example. One of the services that CVS Life Sciences Solutions provides is to make individuals aware of research studies such as this study that may be of interest to them.

You're invited to participate in this study because you recently filled a prescription for ZURZUVAE (zuranolone) at a CVS Specialty® Pharmacy.

The study lasts for 90 days. During this time, you will be asked to complete up to 5 Patient Reported Outcome (PRO) surveys. These surveys ask questions about your experiences while taking ZURZUVAE (zuranolone), as well as other questions regarding your demographic, clinical, and social information. There are no in-person visits or procedures as part of this study.

Steps to participate:

1. If you have not done so already, please go to the study website cvsppd2.studyenrollment.com and sign up to participate.
2. Next, you will be asked to enter a one-time, 6-digit code for authentication. The code will be sent to your email. If you do not see the code in your email, please double check the email you provided at sign-up and check your spam or junk folder.
3. Once the code is entered, you will automatically then move to the study screener. You will also receive an email with a URL link that will open up the study screener. This email is sent just in case you're disconnected when moving from sign up page to screener. You will need to answer the screener questions to see if you're eligible to participate.
4. If you're confirmed eligible, you will then move to the eConsent study platform to review and sign the Informed Consent Form (ICF). You will also receive an email with a URL link that will open up the eConsent study platform. This email is sent just in case you're disconnected when moving from the screener to the ICF.
5. Next, click on 'Sign Informed Consent Form' to review and complete the study ICF.
6. Once you have completed the ICF and signed it electronically, you will receive an email with a URL link to open the 1st survey (Day 0).
7. When you click (select) the URL link in that email, you will be taken to the study website where you will be able to read and complete all of the questions for the 1st survey (Day 0). You will need to complete the 1st survey (Day 0) within the same day of sign-up for participation. You should also complete the 1st survey (Day 0) prior to starting your first dose of ZURZUVAE (zuranolone). If you do not complete the 1st survey (Day 0) before it expires (closes), you will not be able to move forward in participation. If you already took 1 dose (1 day) of ZURZUVAE (zuranolone), then you should complete the ICF and the 1st survey (Day 0) the same day of sign-up for participation and prior to your 2nd dose (2 days) of ZURZUVAE (zuranolone).
8. If you're taking your 1st dose of ZURZUVAE (zuranolone) the same day you enroll in the study and complete the 1st survey (Day 0), you will receive a $50 virtual reward (gift) card that will be sent to your email directly.
9. If you're not planning to take the 1st dose of ZURZUVAE (zuranolone) the same day when you enroll in the study and complete your 1st survey (Day 0), you will receive a $25 virtual reward (gift) card that will be sent to your email directly. You will then receive up to 4 reminder emails within 24 hours of your 1st survey (Day 0) completion to complete your Medication Start Date. Once you have entered the date, your 1st survey (Day 0) will be fully completed and the compensation amount of $25 will be loaded to your virtual reward (gift) card. If you do not enter the date that you took your 1st dose (1 day) of ZURZUVAE (zuranolone) within 24 hours of completing your 1st survey (Day 0), you will not be able to continue participating in the study.
10. An email with a URL link for each additional survey will be sent for Day 3, Day 15, Day 45, and Day 90. Please click (select) the URL within each email and it will take you to the survey study website to read and complete all of the questions for the survey. After you complete EACH survey, the virtual reward (gift) card that you had received will be reloaded with $50 compensation for its completion. After you complete all 5 surveys, you will have received a total of $250 compensation for your time and effort in the study.

No. This study is not meant to provide any medical advice. It is best that you discuss any medical related questions with your current primary care clinician, doctor, or health care team. If you have an emergency, please dial 911.

No. This study does not provide or change any treatment you might be receiving. You will continue to receive care from your current primary care clinician, doctors, and/or other health care providers as usual.

No, your participation is voluntary. This study includes only people who choose to take part. You can decide you do not want to be in this study. Even if you consent and say yes to participating, you can choose to stop participating at any time. If you wish to stop participating at any time, you can contact the call center support team at 855-238-1769 or email the study team at eConsentsupport@CVSHealth.com.

No. All research is completely voluntary, and you have the right to stop participating at any time.

Your study participation will last approximately 90 days.

We plan to enroll up to 200 individuals in the study.

Even if you consent and say yes today, you can choose to stop participating at any time. You can ask questions at any time. Your decision will not affect your relationship with your health care practitioners or your health plan. There are no negative consequences if you choose not to participate in the study. If you do decide to stop participating in the study later, you can contact the call center support team at 855-238-1769 or email the study team at eConsentsupport@CVSHealth.com.

During your study participation, you will be asked to complete up to 5 surveys over the course of 90 days. You will have 24 hours to complete the screener, Informed Consent Form (ICF), and 1st survey (Day 0). If you're not taking ZURZUVAE (zuranolone) the same day you complete the 1st survey (Day 0), you will have an additional 24 hours to complete the Medication Start Date. If you miss the 1st survey (Day 0) or Medication Start Date, you will not be able to continue participating in the study.

After the 1st survey (Day 0), you will also be asked to complete the remaining 4 surveys. For each survey, you will receive an email invitation to complete the survey at that time. You may also receive reminders if you do not complete the survey in timely manner. Each survey has specific deadline for completion, which will be noted in the email invite.

Although we encourage you to complete all 5 surveys, if you do miss one of the surveys following the 1st survey (Day 0), you will receive the invitation and be able to complete the next survey. However, you will only be compensated for the surveys that you complete.

There are no direct healthcare benefits to participating in this study. Your participation in the study will help researchers understand the impacts of ZURZUVAE (zuranolone) on postpartum depression (PPD) related outcomes.

Biogen Inc. is the financial sponsor of this study, which is conducted by the study teams of CVS Life Sciences and Biogen Inc.

The Protected Health Information (PHI) that you provided during prescription filling and registration process at cvs.com and/or at a CVS Pharmacy® including, but not limited to, your name, date of birth, address, gender, race, ethnicity, contact information, and your responses to the testing registration questionnaire (collective, "PHI Testing Data") will be deidentified and summary information will be included in the study.

In addition, the PHI you share in your answers to the 5 Patient Reported Outcomes (PRO) surveys that are a part of the study will also be deidentified and summary information will be included in the study. These surveys ask questions about your symptoms of postpartum depression (PPD) before and after starting ZURZUVAE (zuranolone) over the course of 90 days (collectively, the "PHI Survey Data").

The PHI Testing Data and PHI Survey Data will be accessed and combined with data from other study participants to form a combined set. The combined data set will be de-identified, meaning that any information that could link back to your identity will be removed. This combined data set will be analyzed to understand real-world effectiveness of ZURZUVAE (zuranolone) in individuals that are experiencing symptoms of postpartum depression (PPD).

According to the U.S. Food and Drug Administration (FDA): Real World Evidence (RWE) is the clinical evidence about the usage and benefits or risks of a medical product derived from analysis of Real World Data (RWD). RWE can be used to help monitor and evaluate the post market safety of approved medications or treatments.

According to the U.S. Food and Drug Administration (FDA): Real World Data (RWD) is the data relating to patient or participant health status and/or the delivery of health care routinely collected from a variety of sources. RWD can come from several sources, for example: electronic health records (EHRs), claims and billing activities, product and disease registries.

In line with the study protocol with participants' authorization, CVS Life Sciences Solutions and other data service providers will collect Real World Data (RWD) via participant survey responses or patient-reported outcomes (PROs) in addition to CVS Specialty® Pharmacy data.

CVS Life Sciences Solutions takes the security of your Protected Health Information (PHI)/Personally Identifiable Information (PII) very seriously and has procedures in place to keep your PHI/PII secure. In the event that your PHI/PII is compromised, the study team will alert you and other study participants. It will be kept in a secure environment.

The participant's data or Protected Health Information (PHI)/Personally Identifiable Information (PII) information is collected by CVS Life Sciences Solutions and only available to CVS Life Sciences Solutions study team. CVS Life Sciences Solutions team has an agreement in place with the Sponsor to protect the confidentiality of your information.

Study researchers and data scientists will analyze the data in aggregated (or combined), non-participant level form only, and you cannot be identified individually.

The data collected from this study will still be deidentified, which means your information will not be personally identifiable. That deidentified data will then be aggregated (or combined) with the response data from other participants. Only aggregated data are the interest of this study.

De-identification methods recognized by the Health Insurance Portability and Accountability Act (HIPAA) are Safe Harbor and Expert Determination. You can find more information on Methods for De-identification of Protected Health Services (HHS) by visiting their website at www.hhs.gov/hipaa/for-professionals/special-topics/de-identification.

The aggregated (or combined, not patient-level) study survey results may be published in scientific journals and/or presented at scientific meetings. No personal information will appear in any public or presentation.

You can send your question(s) to eConsentsupport@CVSHealth.com. The study team will get back to you within 1-2 business days. You may also contact the call center support team with your question(s) at 855-238-1769.

You can find more information on Real World Data (RWD) on the U.S. Food and Drug Administration (FDA) website at www.fda.gov/science-research/science-and-research-special-topics/real-world-evidence.

There is no cost to participate in the study. If eligible, you can earn up to a $50 virtual reward (gift) card for taking the 1st survey (Day 0) and confirming the date of your first dose of ZURZUVAE (zuranolone), as well as earn up to $200 more on the virtual reward (gift) card for taking 4 additional surveys (a 2nd survey [Day 3], a 3rd survey [Day 15], a 4th survey [Day 45], and a 5th survey [Day 90]) over 90 days of participation.

Participants will be reimbursed with Mastercard® virtual (or digital) reward cards for their time spent completing the surveys. Participants will provide their email information to receive a virtual reward (gift) card. Information will be provided on how to register and claim your Mastercard® virtual reward (gift) card. For the remainder of the surveys, your virtual reward (gift) card will be reloaded with the designated or assigned compensation amount based on the survey completed.

Based on your responses in the 1st survey (Day 0), you may receive an immediate invite after finishing your 1st survey (Day 0) to complete the Medication Start Date survey by entering the date of your 1st dose of ZURZUVAE (zuranolone). If you do not complete the Medication Start Date survey immediately, you may receive up to 4 email reminders over a 24-hour period to complete the Medication Start Date. If you miss the 1st survey (Day 0) or if you do not enter the date that you took your 1st dose of ZURZUVAE (zuranolone) within 24 hours of your 1st survey (Day 0) completion, you will not be able to continue participating in the study.

You will also be asked to complete a 2nd survey (Day 3), a 3rd survey (Day 15), a 4th survey (Day 45), and a 5th survey (Day 90). For each survey, you will receive an email invite from the study platform to complete the survey at that time. You may also receive up to 4 reminders if you do not complete the survey in a timely manner. After completion of each remaining survey, $50 will be loaded onto your virtual reward (gift) card. You will only be compensated for surveys that you complete.

Once the funds have been added and you have activated your card, you may use the virtual reward (gift) card anywhere debit cards are accepted. Restrictions may apply; see www.MyDashCard.com for more details.

You can find more information about the virtual reward (gift) card by calling DASH support at 1-833-848-5768.

To register your virtual Mastercard® reward (gift) card, visit www.MyDashCard.com to register online and claim your virtual Mastercard® reward (gift) card. Once you visit www.MyDashCard.com, you will click Get Started. Enter your proxy number (which is provided in the email with the virtual reward [gift] card) and then follow the prompts to verify your identity and set-up log in credentials.

You can find more information about the virtual reward (gift) card by calling DASH support at 1-833-848-5678.

To view your virtual reward (gift) card details and balance, scroll down from your dashboard and click Manage Cards to view the balance of the virtual reward (gift) card.

You can find more information about the virtual reward (gift) card by visiting www.MyDashCard.com or by calling DASH support at 1-833-848-5768.

In order for you to receive email alerts of a compensation reload to your virtual reward (gift) card, you will need to enable the feature by visiting www.MyDashCard.com or via the mydashcard app.

Once logged into your profile, you will need to go to "Notification Settings" and go to "Funds Added." When at "Funds Added," you will be able to click (or select) on the envelope icon. By clicking (or selecting) the envelope icon, this will enable the feature to allow for notification of a reload to the virtual reward (gift) card.

You may also click (or select) the text bubble icon located next to the envelope icon and get SMS text notifications of reloads of the virtual reward (gift) card. Please note that Standard data rates may apply for SMS text notifications.

Provide your virtual reward (gift) card details to make online purchases where appropriate when making the online purchase or click Add to Wallet when in www.MyDashCard.com to add card details to your phone's digital wallet for in-store purchases.

You can find more information about the virtual reward (gift) card by calling DASH support at 1-833-848-5768.

If you do not see your virtual reward (gift) card in your email inbox, please check your spam or junk folder. The email with information for your virtual reward (gift) card may have accidentally been sent there instead.

If you do not see it there, please contact the CVS Life Sciences Solutions study team at eConsentsupport@CVSHealth.com. The study team will get back to you within 1-2 business days.

Yes, once logged into the MyDashCard app or website, you can request a physical card by navigating to "More" on the home page and by selecting "Add Physical Card." Verify your mailing address is correct and follow the prompts to have a physical card mailed to you. If your mailing address is incorrect, you can update it by contacting DASH customer service by calling 1-833-848-5768 or by contacting the study team via eConsentsupport@CVSHealth.com.

Once you request a physical reward (gift) card, the card takes about three (3) to five (5) business days to create. Once your physical reward (gift) card is created, the card will then ship standard United States Postal Service (USPS) shipping to the address on file. There is no tracking available for shipping but shipped cards typically take about five (5) to seven (7) business days to arrive.

If you wish to have your physical reward (gift) card arrive sooner, you can request for expedited shipping for an additional fee by contacting DASH customer service by calling 1-833-848-5768 or by contacting the study team via eConsentsupport@CVSHealth.com. You must submit your request for expedited shipping by 11AM ET the day after the physical reward (gift) card is ordered. Please note that the additional expedited shipping fee will be applied to your physical reward (gift) card amount.

Once the physical reward (gift) card is issued and if you need to update your shipping address, you will need to go through DASH Support via www.MyDashCard.com or by calling 1-833-848-5768 and provide documentation of the address. Documentation is needed to prevent any fraudulent requests.

Once funds have been added and you have activated your physical reward (gift) card, you may use the physical reward (gift) card for purchases anywhere Debit Mastercard® is accepted.

You can find more information about the physical reward (gift) card by visiting www.MyDashCard.com or by calling DASH support at 1-833-848-5768.

You may check your balance 24 hours a day, 7 days a week by calling DASH support at 1-833-848-5768. Key in your card number and three-digit security code found on the back of the Card. You may also check your balance by visiting www.MyDashCard.com.

You may also spend the available balance on your Mastercard® prepaid physical reward (gift) card. You may pay the difference between the purchase price and the remaining value of the physical reward (gift) card with cash, check, another credit/debit card or another form of payment. This is subject to merchant's procedures.

You can find more information about the physical reward (gift) card by visiting www.MyDashCard.com or by calling DASH support at 1-833-848-5768.

If you still have available funds, a decline means that the amount authorized by the merchant is above the remaining balance on the physical reward (gift) card. Be sure the merchant is only authorizing an amount that is equal to or less than the current balance.

You can find more information about the physical reward (gift) card by visiting www.MyDashCard.com or by calling DASH support at 1-833-848-5768.

You may use your card until the balance is zero, or in the case of an expired card, a new card will be sent. If you do not receive a new card, you may call DASH support at 1-833-848-5768 to request a new card or visit www.MyDashCard.com for more information.

Merchants may preauthorize amounts to your physical reward (gift) card based on the purchase type, potentially causing your physical reward (gift) card to decline if your physical reward (gift) card balance is not sufficient to cover the preauthorized amount. If the preauthorization amount is authorized, it will restrict those funds from use until the merchant presents the transaction for payment. To purchase gasoline, take your physical reward (gift) card inside and ask the attendant to charge an amount equal to or less than the remaining balance on your physical reward (gift) card. To pay for rental cars, hotels, and other items or services where the merchant preauthorizes an amount, you may choose to hold the purchase using a personal physical reward card and, at the time of checkout/settlement, use your Mastercard® prepaid physical reward (gift) card to settle the final transactions amount.

You can find more information about the physical reward (gift) card by visiting www.MyDashCard.com or by calling DASH support at 1-833-848-5768.

A PIN is not required to make a purchase, simply select "credit" and sign the receipt. If you desire a PIN, call DASH support at 1-833-848-5768. Obtaining a PIN will enable you to withdraw funds at an ATM that displays the Mastercard® or PLUS logo or provide cash back with a transaction at merchants that permit this transaction type. Cashback transactions are subject to the merchant's procedures. ATM transactions are subject to daily withdrawal maximums and the ATM owner's procedures.

You can find more information about the physical reward (gift) card by also visiting www.MyDashCard.com.

A lost or stolen card replacement fee may be charged if the physical reward (gift) card is replaced. See the Cardholder Agreement Terms and Conditions provided with the card for more details.

You can find more information about the physical reward (gift) card by visiting www.MyDashCard.com or by calling DASH support at 1-833-848-5768.

No, funds are only loaded through your program administrator.

If you need any help with your funds, please contact the CVS Life Sciences Solutions team at eConsentsupport@CVSHealth.com.

To report a lost or stolen card immediately, check your balance or get information via www.MyDashCard.com or call DASH support at 1-833-848-5768.

For the best experience, please use the latest version of the following browsers:

• Google Chrome
• Mozilla Firefox
• Safari
• Microsoft Edge

These browsers are supported on any operating system. It is important to use an up-to-date browser for compatibility and to receive the latest security updates.

Please note that Internet Explorer is no longer supported. You may experience issues if you attempt to access the Castor eConsent platform using the browser.

For older browser versions, the Castor eConsent platform may function on the outdated browser versions. However, you may notice some minor impacts on the user interface. Outdated browsers also may not recognize the scripts running in the background, leading to potential issues when trying to complete the study.

Only individuals who were invited by the CVS Life Sciences Solutions study team directly via email are able to participate in the study. If you did receive an email to participate in the study, please make sure you have entered your first name, last name, and date of birth in the sign-up fields correctly. This information is checked against CVS Life Sciences Solutions records to make sure that the potential participant signing-up to participate in the study matches our records.

If the information is correct and you're still receiving an error message, please reach out to the CVS Life Sciences Solutions study team at eConsentsupport@CVSHealth.com and they will be able to work with you on next steps and work with you to quickly resolve the issue.

You will also want to confirm that your information is correct at your local CVS Pharmacy® and Minute Clinic®. Please contact staff at your local CVS Pharmacy® and Minute Clinic® to make sure your information is correct or if it needs to be updated.

For this study, there are strict inclusion and exclusion criteria in order to be able to participate. The screener questions make sure a potential participant is eligible to participate. If you were notified that you're ineligible and unable to participate in the study, it was because one of your responses in the screener may have deemed you ineligible to participate at this time. If you do truly believe there has been a mistake and you should be eligible to participate, please contact eConsentsupport@CVSHealth.com and the CVS Life Sciences Solutions study team will review your responses with you.

If you do not see the email with the one-time code, please check to see if the email that you entered in at the time of signing up is correct. If correct, please check your spam or junk folder for emails coming from EDC Castor/CVS Clinical Studies. If incorrect, please try entering your information in again in the sign up. You should then receive the email with one-time code.

You can also contact eConsentsupport@CVSHealth.com for help. Please allow 1-2 business days for a reply. You may also contact the call center support team at 855-238-1769.

If you do not see the invitation to sign the consent form in your email inbox, please check your spam or junk folder for emails coming from EDC Castor/CVS Clinical Studies.

You can contact eConsentsupport@CVSHealth.com with help regarding the informed consent form. Please allow 1-2 business days for a reply. You may also contact the call center support team at 855-238-1769.

Please contact eConsentsupport@CVSHealth.com with help regarding the consent form. Please allow 1-2 business days for a reply. You may also contact the call center support team at 855-238-1769 to troubleshoot over the phone.

If you do not see the invitation to start the next survey in your email inbox, please check your spam or junk folder for emails coming from EDC Castor/CVS Clinical Studies.

You may contact eConsentsupport@CVSHealth.com for help. Please allow 1-2 business days for a reply. You may also contact the call center support team at 855-238-1769.

You may not see a question appear in the survey due to the design of the survey and the responses that you have provided; some questions are dependent on an answer supplied in a previous question in order for them to appear while completing the survey.

If you believe there is a mistake, please contact eConsentsupport@CVSHealth.com. Please allow 1-2 business days for a reply. You may also contact the call center support team at 855-238-1769 to troubleshoot over the phone.

Yes, you can change your email and our study team will update it. All future surveys will go to the new email address once the updated email is processed.

Please contact eConsentsupport@CVSHealth.com with help to update your email. You may also contact the call center support team at 855-238-1769 to troubleshoot over the phone.

You can opt out of SMS text notification and reminders at any time during your participation. You will still receive email reminders for the study. To opt out of SMS text notifications, please contact the call center support team at 855-238-1769.

You can withdraw or unsubscribe from the study at any time during your participation. To withdraw or unsubscribe from the study, please contact the call center support team at 855-238-1769.